<link>https://www.igp.uu.se/research_news</link> <description /> <item> <title>Quiescent cancer cells potential target for colorectal cancer therapy https://www.igp.uu.se/research_news?tarContentId=1078050&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>For patients with colorectal cancer the tumour often recurs since quiescent cancer cells can escape therapy and start growing again. In a study from IGP, the researchers have discovered a protein that identifies such quiescent cancer cells. This could improve the possibilities to eliminate also these cells and ultimately lead to more effective therapy.</p> Wed, 07 Feb 2024 09:47:00 GMT https://www.igp.uu.se/research_news?tarContentId=1078050&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2024-02-07T09:47:00Z Patients with precursor stage of malignant melanoma show better survival than people in general https://www.igp.uu.se/research_news?tarContentId=1074214&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Malignant melanoma is the cancer type that show the largest increase in Sweden. A study from IGP shows that patients with a precursor stage of malignant melanoma have a significantly better survival than the population in general, despite an increased risk of being diagnosed with malignant melanoma. The results have been published in the journal eClinicalMedicine/The Lancet.</p> Wed, 13 Dec 2023 08:35:00 GMT https://www.igp.uu.se/research_news?tarContentId=1074214&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-12-13T08:35:00Z Clinical symptoms in rheumatoid arthritis are associated with specific autoantibodies https://www.igp.uu.se/research_news?tarContentId=1073968&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>The presence of different autoantibodies associated with rheumatoid arthritis should be evaluated separately to provide a better picture of prognosis and support for treatment decisions. This is shown in a new study from IGP, published in the recognised journal Annals of the Rheumatic Diseases.</p> Wed, 06 Dec 2023 14:44:00 GMT https://www.igp.uu.se/research_news?tarContentId=1073968&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-12-06T14:44:00Z Genetics influence the risk of blood clots in oral contraceptive users https://www.igp.uu.se/research_news?tarContentId=1069960&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Women with a high genetic predisposition for blood clots are six times more likely to develop a blood clot during the first two years of using contraceptive pills according to a new study from IGP. The results have been published in the American Journal of Obstetrics and Gynaecology.</p> Fri, 20 Oct 2023 07:30:00 GMT https://www.igp.uu.se/research_news?tarContentId=1069960&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-10-20T07:30:00Z Contraceptive pills protect against rheumatoid arthritis https://www.igp.uu.se/research_news?tarContentId=1069340&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Contraceptive pills can reduce the risk of rheumatoid arthritis, while hormone treatment in connection with menopause can increase the risk later in life. In a new study of more than 200,000 women in the UK, researchers at IGP have discovered connections between the use of sex hormones and the risk of developing rheumatoid arthritis. The results have been published in the journal Rheumatology.</p> Wed, 11 Oct 2023 08:49:00 GMT https://www.igp.uu.se/research_news?tarContentId=1069340&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-10-11T08:49:00Z New mechanism behind cancer cell growth revealed https://www.igp.uu.se/research_news?tarContentId=1068344&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>The protein EZH2 can interact with a specific RNA molecule to block genes that are important for tumour growth. This is shown in a new study from IGP that reveals one of the mechanisms behind the growth of cancer cells in the blood cancer multiple myeloma. These findings might contribute to the development of new treatments for multiple myeloma patients. The study is published in the journal Haematologica.</p> Wed, 27 Sep 2023 11:34:00 GMT https://www.igp.uu.se/research_news?tarContentId=1068344&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-09-27T11:34:00Z Improved tumour killing immune cells against brain cancers https://www.igp.uu.se/research_news?tarContentId=1065864&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have demonstrated a mechanism for how cancer killing immune cells called CAR- T cells sometimes are prematurely exhausted and fail to kill the cancer cells. They also present new CAR-T cells against brain tumours that lack this unwanted exhaustion feature. The future aim is to use these CAR-T cells to treat brain cancer. The study has been published in the journal Nature Communications.</p> Tue, 22 Aug 2023 06:20:00 GMT https://www.igp.uu.se/research_news?tarContentId=1065864&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-08-22T06:20:00Z New method to identify mutations in childhood brain tumours https://www.igp.uu.se/research_news?tarContentId=1065536&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have developed a new method to find mutations in brain tumours in children. They could also show that the mutations identified by them changes how cancer cells respond to a cancer drug. These findings could lead to better diagnostics and more individualized treatment of children with brain tumours.</p> Mon, 14 Aug 2023 09:40:00 GMT https://www.igp.uu.se/research_news?tarContentId=1065536&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-08-14T09:40:00Z Newly discovered genetic abnormality affects leukemia prognosis https://www.igp.uu.se/research_news?tarContentId=1064170&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>The blood cancer form acute myeloid leukemia (AML) is an extremely heterogeneous disease where disease development and therapeutic approach are mainly dictaded by genetic alterations in the malignant cells. In a recent study from IGP, the researchers show that a certain type of abnormality in the gene <em>RUNX1</em> affects the classification of patients with AML and thereby the optimal therapy selection.</p> Tue, 04 Jul 2023 06:28:00 GMT https://www.igp.uu.se/research_news?tarContentId=1064170&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-07-04T06:28:00Z Link between obesity and cancer risk depends on sex and cancer type https://www.igp.uu.se/research_news?tarContentId=1063824&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Many studies have linked obesity to an increased risk of cancer, but most have not differentiated the risks between men and women. In a new study, researchers from IGP take a closer look at this connection. The investigators report that both overall fat accumulation and fat distribution in different parts of the body confer different cancer risks depending on biological sex. Additionally, the risks vary across cancer types. The results are published in the journal Cancer Cell.</p> Mon, 26 Jun 2023 07:33:00 GMT https://www.igp.uu.se/research_news?tarContentId=1063824&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-06-26T07:33:00Z New study links contraceptive pills and depression https://www.igp.uu.se/research_news?tarContentId=1063060&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study from IGP. Contraceptive pills increased women&rsquo;s risk by 73 per cent during the first two years of use.</p> Mon, 19 Jun 2023 09:23:00 GMT https://www.igp.uu.se/research_news?tarContentId=1063060&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-06-19T09:23:00Z High BMI increases the risk of several rheumatic diseases – but not equally for everyone https://www.igp.uu.se/research_news?tarContentId=1063018&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>A new study from IGP shows that a higher body mass index (BMI) increases the risk of five different rheumatic diseases; rheumatism, osteoarthritis, gout, psoriatic arthritis and inflammatory spondylitis. The researchers were also able to see that BMI was a stronger risk factor for women compared to men when it came to the diseases gout and psoriatic arthritis. The study is presented in the scientific journal Arthritis and Rheumatology.</p> Mon, 19 Jun 2023 07:34:00 GMT https://www.igp.uu.se/research_news?tarContentId=1063018&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-06-19T07:34:00Z New therapy helps immune system eradicate brain tumours https://www.igp.uu.se/research_news?tarContentId=1060414&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers from IGP have developed a method that helps immune cells exit from blood vessels into the tumour and kill cancer cells. The aim is to improve treatment of aggressive brain tumours. The study has been published in the journal Cancer Cell.</p> Fri, 12 May 2023 07:25:00 GMT https://www.igp.uu.se/research_news?tarContentId=1060414&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-05-12T07:25:00Z Genomes from 240 mammal species explain human disease risks https://www.igp.uu.se/research_news?tarContentId=1060012&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>In a large international project jointly led by Uppsala University and the Broad Institute, more than 30 research teams have together surveyed and analysed the genomes of 240 mammal species. The results, now published in 11 articles in the journal Science, show mutations that can cause disease. Karin Forsberg Nilsson and Ananya Roy at IGP have participated in one of the papers, where they have identified mutations associated with the cancer type medulloblastoma.</p> Fri, 05 May 2023 10:42:00 GMT https://www.igp.uu.se/research_news?tarContentId=1060012&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-05-05T10:42:00Z IRAK3 protein affects response to cancer immunotherapy https://www.igp.uu.se/research_news?tarContentId=1059978&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>A recent study by IGP researchers shows that the protein IRAK3 reduces the effect of immunotherapy against cancer. One way of improving the therapy response could be to reduce the amount the IRAK3 with drugs that target the protein. &nbsp;</p> Fri, 05 May 2023 08:07:00 GMT https://www.igp.uu.se/research_news?tarContentId=1059978&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-05-05T08:07:00Z Increased risk of testicular cancer in men with autism and ADHD https://www.igp.uu.se/research_news?tarContentId=1059342&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>A new study by researchers at IGP shows that men who have a neurodevelopmental disorder, such as autism and ADHD, also have a slightly increased risk of testicular cancer, or seminoma.</p> Tue, 25 Apr 2023 06:23:00 GMT https://www.igp.uu.se/research_news?tarContentId=1059342&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-04-25T06:23:00Z One of Vasa’s crewmen was a woman https://www.igp.uu.se/research_news?tarContentId=1057926&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>When the human remains found on board the warship Vasa were investigated, it was determined that they were all male. New research now shows that one of the skeletons is actually from a woman.</p> Thu, 06 Apr 2023 07:23:00 GMT https://www.igp.uu.se/research_news?tarContentId=1057926&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-04-06T07:23:00Z Immune cells in tumours can predict disease progression and therapy response https://www.igp.uu.se/research_news?tarContentId=1050056&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have identified a combination of two types of immune cells that characterise certain cancer forms. This combination can be used to provide disease prognosis and predict treatment response to immunotherapy. The findings are presented in a new study in the journal eBioMedicine.</p> Tue, 31 Jan 2023 07:28:00 GMT https://www.igp.uu.se/research_news?tarContentId=1050056&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-01-31T07:28:00Z Newly discovered cell type interplays with immune cells in vascular disease https://www.igp.uu.se/research_news?tarContentId=1048734&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have discovered a new cell subtype in the lymphatic vessels that interacts with immune cells in lymphatic malformations. This newly discovered interplay between the immune system and the lymphatic system could be used to treat diseases with lymphatic malformations.</p> Mon, 23 Jan 2023 15:32:00 GMT https://www.igp.uu.se/research_news?tarContentId=1048734&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2023-01-23T15:32:00Z The Yes protein controls leakage from blood vessel to surrounding tissues https://www.igp.uu.se/research_news?tarContentId=1040288&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have identified a protein involved in regulating leakage from blood vessel. Its role in controlling cell&ndash;cell contacts, challenges prior knowledge and opens up new avenues for future therapeutic development in diseases involving vessel leakage and tissue swelling.</p> Mon, 19 Dec 2022 14:27:00 GMT https://www.igp.uu.se/research_news?tarContentId=1040288&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-12-19T14:27:00Z Y chromosome loss linked to men's increased risk of severe COVID-19 https://www.igp.uu.se/research_news?tarContentId=1038414&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Men are at an increased risk of a severe bout of COVID-19 compared to women. Researchers at IGP have now shown that this may be due to loss of the Y chromosome in part of their white blood cells. The findings could eventually be used to assess the risk of developing severe COVID-19 and perhaps to improve treatment.</p> Thu, 15 Dec 2022 07:17:00 GMT https://www.igp.uu.se/research_news?tarContentId=1038414&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-12-15T07:17:00Z A stem cell protein facilitates relapse of pediatric brain tumours https://www.igp.uu.se/research_news?tarContentId=1032456&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>The malignant brain tumour type medulloblastoma can become resistant to therapy which can cause relapse. Researchers at IGP have discovered a certain protein that among other things makes tumour cells resting and insensitive to radiation treatment. The research group hopes that the results could eventually lead to better treatments for children that have the highest risk to develop relapses.</p> Fri, 28 Oct 2022 08:58:00 GMT https://www.igp.uu.se/research_news?tarContentId=1032456&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-10-28T08:58:00Z Pigment-producing cells in the skin protect against sunlight and genetic damage https://www.igp.uu.se/research_news?tarContentId=1031800&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Single periods of sun exposure or radiation therapy to the skin likely pose a minimal risk of skin cancer. This is suggested in a study from IGP where the researchers have shown that pigment-producing cells in the skin can skin can tolerate long-term exposure of genetic injuries by changing between different degrees of maturity.</p> Mon, 24 Oct 2022 08:59:00 GMT https://www.igp.uu.se/research_news?tarContentId=1031800&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-10-24T08:59:00Z New tool could be applied during drug development and in the clinic https://www.igp.uu.se/research_news?tarContentId=1031362&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researcher at IGP have developed a new tool that enables the visualisation where drugs bind to human proteins. The highly sensitive technique can be used in searches for compounds with specificity for particular target proteins. It could be used in drug discovery processes or to establish the suitability of a given drug regime before therapy selection.</p> Wed, 19 Oct 2022 09:54:00 GMT https://www.igp.uu.se/research_news?tarContentId=1031362&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-10-19T09:54:00Z Widespread metabolic dysregulation in different organs in type 2 diabetes https://www.igp.uu.se/research_news?tarContentId=1029326&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Using state of the art techniques, researchers from Uppsala University have shown that the metabolism in patients with type 2 diabetes and prediabetes was much more disturbed than previously known, and that it varied between organs and with the severity of the disease. The study, which is a collaboration with Copenhagen University and AstraZeneca, among others, has been published in the journal Cell Reports Medicine.</p> Fri, 07 Oct 2022 12:02:00 GMT https://www.igp.uu.se/research_news?tarContentId=1029326&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-10-07T12:02:00Z Genetic background associated with physically active lifestyle https://www.igp.uu.se/research_news?tarContentId=1025440&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>In a large international study, researchers at IGP have identified DNA regions that are associated with physical activity or leisure screen time. The findings confirm that physical activity is beneficial for health and suggest that a more sedentary lifestyle can be due to how the muscles respond to exercise.</p> Thu, 08 Sep 2022 06:26:00 GMT https://www.igp.uu.se/research_news?tarContentId=1025440&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-09-08T06:26:00Z Blood clot formation in cerebral cavernous malformations https://www.igp.uu.se/research_news?tarContentId=1022862&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Blood coagulation and blood clot formation are relevant for the disease cerebral cavernoma, CCM. Therefore, antithrombotic therapy may be beneficial for cavernoma patients. This is shown in a new study from IGP.</p> Tue, 23 Aug 2022 12:48:00 GMT https://www.igp.uu.se/research_news?tarContentId=1022862&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-08-23T12:48:00Z Y chromosome loss causes heart failure and death from cardiovascular disease https://www.igp.uu.se/research_news?tarContentId=1020904&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Loss of the Y chromosome in blood cells of men is associated with disease and mortality, but no clear causal relationship has previously been identified. Now, researchers from IGP show in an international study in the journal Science that loss of the Y chromosome in white blood cells causes development of fibrosis in the heart, impaired heart function and death from cardiovascular diseases in men.</p> Thu, 14 Jul 2022 18:45:00 GMT https://www.igp.uu.se/research_news?tarContentId=1020904&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-07-14T18:45:00Z Alternative promising approach for sensitive protein detection https://www.igp.uu.se/research_news?tarContentId=1020800&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have developed a new method to detect proteins with high specificity and sensitivity that could be use in future diagnostic analyses of patient samples.</p> Fri, 08 Jul 2022 13:00:00 GMT https://www.igp.uu.se/research_news?tarContentId=1020800&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-07-08T13:00:00Z Oral contraceptives and hormone treatment increase stroke risk https://www.igp.uu.se/research_news?tarContentId=1019920&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>A new study from IGP show that oral contraceptives and also hormone replacement therapy at menopause increase the risk of stroke. The increased risk was largest during the first year of treatment, after which it declined. The study, which is now published in the journal Stroke, is based on data from more than a quarter of a million women from the database UK Biobank.</p> Mon, 27 Jun 2022 07:09:00 GMT https://www.igp.uu.se/research_news?tarContentId=1019920&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-06-27T07:09:00Z Rare genetic variants are not the main cause of common diseases https://www.igp.uu.se/research_news?tarContentId=1014400&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Although some rare variants can significantly increase the risk of disease for a few individuals, the majority of the genetic contribution to common diseases is due to a combination of many common genetic variants with small effects. This is shown by researchers at IGP and other departments at Uppsala University in a new comprehensive study published in the journal Nature Communications.</p> Fri, 13 May 2022 08:15:00 GMT https://www.igp.uu.se/research_news?tarContentId=1014400&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-05-13T08:15:00Z Subgroups of brain tumours associated with cell origin and disease prognosis https://www.igp.uu.se/research_news?tarContentId=1011174&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have detected different subgroups of the brain tumour form glioblastoma, where the cancer cells&rsquo; properties depend on which cell type they originate from. The used analysis method could also separate glioblastoma patients with significant differences in survival. The findings open up for identifying specific therapeutic targets for the new subgroups of glioblastoma.</p> Mon, 25 Apr 2022 10:51:00 GMT https://www.igp.uu.se/research_news?tarContentId=1011174&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-04-25T10:51:00Z Armed CAR-T cells to better fight cancer https://www.igp.uu.se/research_news?tarContentId=1008792&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Immunotherapy is increasingly becoming a successful way to treat cancer. Researchers at IGP have now developed armed CAR-T cells that reinforce the immune defence against cancer and that could increase the possibilities to successfully treat solid tumours. The study has been published in the journal Nature BioMedical Engineering.</p> Mon, 04 Apr 2022 07:01:00 GMT https://www.igp.uu.se/research_news?tarContentId=1008792&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-04-04T07:01:00Z Inflammation and net-like protein structures in cerebral cavernous malformations https://www.igp.uu.se/research_news?tarContentId=1007334&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>In the condition known as cavernoma, lesions arise in a cluster of blood vessels in the brain, spinal cord or retina. Researchers at IGP now show in a new study that white blood cells and protein structures associated with the immune response infiltrate the vessel lesions. The findings support that inflammation has a role in the development of cavernoma and indicate a potential biomarker for the disease. &nbsp;</p> Mon, 28 Mar 2022 08:17:00 GMT https://www.igp.uu.se/research_news?tarContentId=1007334&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-03-28T08:17:00Z Protein landscape on cancer cells mapped with new technology https://www.igp.uu.se/research_news?tarContentId=1001430&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>In recent years, great advances have been made in the development of new, successful immunotherapies to treat cancer. Two types of targeted immunotherapies that have revolutionised areas of cancer care are CAR T-cell therapy and antibody treatments. However, there are still significant challenges in the identification of cancer cell surface proteins that function as targets for immunotherapies. Mattias Belting, professor at Lund University and senior consultant at Sk&aring;ne University Hospital, and guest professor at IGP, is well on the way and his group&rsquo;s findings are now published in the journal PNAS.</p> Thu, 03 Mar 2022 11:48:00 GMT https://www.igp.uu.se/research_news?tarContentId=1001430&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-03-03T11:48:00Z CRISPR-Cas9 can generate unexpected, heritable mutations https://www.igp.uu.se/research_news?tarContentId=993672&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>CRISPR-Cas9, the &ldquo;genetic scissors&rdquo;, creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation. These scientists therefore urge caution and meticulous validation before using CRISPR-Cas9 for medical purposes.</p> Thu, 03 Feb 2022 16:08:00 GMT https://www.igp.uu.se/research_news?tarContentId=993672&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-02-03T16:08:00Z New technology to study DNA in archived tissue samples https://www.igp.uu.se/research_news?tarContentId=989710&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>Researchers at IGP have developed a technology that allows studies of DNA profiles in archived tissue samples. The technology permits investigators to better understand regulation of gene activity in cancer and precision medicine.</p> Wed, 19 Jan 2022 08:34:00 GMT https://www.igp.uu.se/research_news?tarContentId=989710&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-01-19T08:34:00Z New genes associated with relapse of acute myeloid leukemia https://www.igp.uu.se/research_news?tarContentId=988582&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 <p>In the blood cancer type acute myeloid leukemia, it is common that patients relapse some time after treatment. Researchers from IGP have in a new study identified genes that seem to be associated with the risk of relapse. The findings may form the basis for new treatment strategies and contribute to better survival for patients with acute myeloid leukemia.</p> Thu, 13 Jan 2022 16:04:00 GMT https://www.igp.uu.se/research_news?tarContentId=988582&rssTarget=791610&rssTitle=&newsDetailSiteNodeId=198036&newsListSiteNodeId=198036&showLeadIn=true&languageId=1&positionId=543652 2022-01-13T16:04:00Z